{"id":44199,"date":"2024-08-20T10:30:22","date_gmt":"2024-08-20T03:30:22","guid":{"rendered":"https:\/\/e1ship.com\/?p=44199"},"modified":"2024-08-21T10:49:58","modified_gmt":"2024-08-21T03:49:58","slug":"danh-gia-tinh-an-toan-va-hieu-qua-cua-enoxaparin-lieu-dung-mot-lan-moi-ngay","status":"publish","type":"post","link":"https:\/\/e1ship.com\/danh-gia-tinh-an-toan-va-hieu-qua-cua-enoxaparin-lieu-dung-mot-lan-moi-ngay.html","title":{"rendered":"\u0110\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a Enoxaparin li\u1ec1u d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y so v\u1edbi hai l\u1ea7n m\u1ed7i ng\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng VTE \u1edf b\u1ec7nh nhi"},"content":{"rendered":"<h2 style=\"text-align: justify;\"><strong>B\u1ed1i c\u1ea3nh v\u00e0 m\u1ee5c ti\u00eau nghi\u00ean c\u1ee9u<\/strong><\/h2>\n<p style=\"text-align: justify;\">Enoxaparin l\u00e0 m\u1ed9t heparin c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed th\u1ea5p v\u00e0 b\u1eb1ng kho\u1ea3ng 1\/3 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed c\u1ee7a heparin th\u00f4ng th\u01b0\u1eddng (kh\u00f4ng ph\u00e2n \u0111o\u1ea1n) (4.500\/12.000 daltons) v\u00e0 l\u00e0 m\u1ed9t thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng ti\u00eam ph\u1ed5 bi\u1ebfn hi\u1ec7n nay. M\u1ed9t trong c\u00e1c ch\u1ec9 \u0111\u1ecbnh quan tr\u1ecdng c\u1ee7a thu\u1ed1c l\u00e0 \u0111\u1ec3 d\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c tr\u01b0\u1eddng h\u1ee3p thuy\u00ean t\u1eafc huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch (venous thromboembolism, VTE). Tr\u00ean b\u1ec7nh nh\u00e2n nhi, enoxaparin \u0111\u01b0\u1ee3c d\u00f9ng li\u1ec1u hai l\u1ea7n m\u1ed9t ng\u00e0y. Li\u1ec1u m\u1ed9t l\u1ea7n m\u1ed9t ng\u00e0y nh\u01b0 \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn \u00edt \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng v\u00ec thi\u1ebfu d\u1eef li\u1ec7u v\u1ec1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3. M\u1ee5c ti\u00eau c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y nh\u1eb1m \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a enoxaparin d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed9t ng\u00e0y so v\u1edbi vi\u1ec7c d\u00f9ng hai l\u1ea7n m\u1ed9t ng\u00e0y trong d\u1ef1 ph\u00f2ng VTE \u1edf tr\u1ebb em.<\/p>\n<p style=\"text-align: justify;\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-44200\" src=\"https:\/\/e1ship.com\/wp-content\/uploads\/2024\/08\/Danh-gia-tinh-an-toan-va-hieu-qua-cua-Enoxaparin-1.jpg\" alt=\"\" width=\"650\" height=\"390\" \/><\/p>\n<h2 style=\"text-align: justify;\"><strong>Ph\u01b0\u01a1ng ph\u00e1p<\/strong><strong> nghi\u00ean c\u1ee9u<\/strong><\/h2>\n<p style=\"text-align: justify;\">Nghi\u00ean c\u1ee9u h\u1ed3i c\u1ee9u tr\u00ean b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng enoxaparin \u0111\u1ec3 d\u1ef1 ph\u00f2ng VTE t\u1eeb th\u00e1ng 10 n\u0103m 2018 \u0111\u1ebfn th\u00e1ng 9 n\u0103m 2021 t\u1ea1i Trung t\u00e2m Y t\u1ebf tr\u1ebb em Cohen, New Hyde Park, New York, Hoa K\u1ef3. C\u00e1c b\u1ec7nh nh\u00e2n tr\u00ean 18 tu\u1ed5i ho\u1eb7c b\u1ec7nh nh\u00e2n nhi c\u00f3 suy th\u1eadn v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinine &lt; 30 mL\/ph\u00fat\/1,73m<sup>2<\/sup> t\u00ednh theo c\u00f4ng th\u1ee9c Schwartz \u0111\u01b0\u1ee3c lo\u1ea1i kh\u1ecfi nghi\u00ean c\u1ee9u.<\/p>\n<p style=\"text-align: justify;\">Ch\u1ec9 ti\u00eau nghi\u00ean c\u1ee9u l\u00e0 t\u1ef7 l\u1ec7 g\u1eb7p bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i v\u00e0 ch\u1ea3y m\u00e1u trong qu\u00e1 tr\u00ecnh theo d\u00f5i.<\/p>\n<h2 style=\"text-align: justify;\"><strong>K\u1ebft qu\u1ea3 <\/strong><\/h2>\n<p style=\"text-align: justify;\">Trong s\u1ed1 202 b\u1ec7nh nh\u00e2n nhi \u0111\u00e3 d\u00f9ng enoxaparin c\u00f3 159 tr\u01b0\u1eddng h\u1ee3p \u0111\u00e1p \u1ee9ng ti\u00eau chu\u1ea9n l\u1ef1a ch\u1ecdn v\u00e0 lo\u1ea1i tr\u1eeb v\u1edbi t\u1ed5ng s\u1ed1 177 l\u01b0\u1ee3t ph\u00f2ng b\u1eb1ng enoxaparin ti\u00eam d\u01b0\u1edbi da \u0111\u01b0\u1ee3c ghi nh\u1eadn. Trong t\u1ed5ng s\u1ed1 l\u01b0\u1ee3t d\u1ef1 ph\u00f2ng c\u00f3 81 tr\u01b0\u1eddng h\u1ee3p d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed9t ng\u00e0y v\u00e0 96 tr\u01b0\u1eddng h\u1ee3p d\u00f9ng hai l\u1ea7n m\u1ed9t ng\u00e0y.<\/p>\n<p style=\"text-align: justify;\">Li\u1ec1u trung b\u00ecnh \u1edf nh\u00f3m d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y l\u00e0 0,68 mg\/kg\/li\u1ec1u trong khi li\u1ec1u \u1edf nh\u00f3m d\u00f9ng hai l\u1ea7n m\u1ed7i ng\u00e0y l\u00e0 0,49 mg\/kg\/li\u1ec1u. Th\u1eddi gian d\u1ef1 ph\u00f2ng k\u00e9o d\u00e0i &gt;30 ng\u00e0y \u1edf nh\u00f3m d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed9t ng\u00e0y (22%) h\u01a1n \u1edf nh\u00f3m d\u00f9ng hai ng\u00e0y m\u1ed9t l\u1ea7n (4,2%) <strong><em>(B\u1ea3ng 1)<\/em><\/strong>.<\/p>\n<p style=\"text-align: center;\"><strong><em>B\u1ea3ng 1. <\/em><\/strong><em>C\u00e1c \u0111\u1eb7c \u0111i\u1ec3m ch\u1ebf \u0111\u1ed9 li\u1ec1u<\/em><\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-44201\" src=\"https:\/\/e1ship.com\/wp-content\/uploads\/2024\/08\/Danh-gia-tinh-an-toan-va-hieu-qua-cua-Enoxaparin_Bang-1.png\" alt=\"\" width=\"800\" height=\"291\" \/><\/p>\n<p style=\"text-align: justify;\">T\u1ec9 l\u1ec7\/s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n g\u1eb7p huy\u1ebft kh\u1ed1i: c\u00f3 01 b\u1ec7nh nh\u00e2n trong nh\u00f3m d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed9t ng\u00e0y b\u1ecb huy\u1ebft kh\u1ed1i, kh\u00f4ng c\u00f3 b\u1ec7nh nh\u00e2n trong nh\u00f3m d\u00f9ng thu\u1ed1c hai l\u1ea7n m\u1ed7i ng\u00e0y nh\u01b0ng kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea\u00a0 (p = 0,46; <strong><em>B\u1ea3ng <\/em><\/strong><strong><em>2<\/em><\/strong>). Sau khi \u0111i\u1ec1u tra th\u00eam, bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i trong nghi\u00ean c\u1ee9u x\u1ea3y ra l\u00e0 huy\u1ebft kh\u1ed1i li\u00ean quan \u0111\u1ebfn \u1ed1ng th\u00f4ng n\u00f4ng. V\u1ec1 Bi\u1ebfn c\u1ed1 ch\u1ea3y m\u00e1u: C\u00f3 1 tr\u01b0\u1eddng h\u1ee3p ch\u1ea3y m\u00e1u n\u1eb7ng (1,2%) \u1edf nh\u00f3m d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y v\u00e0 kh\u00f4ng c\u00f3 ch\u1ea3y m\u00e1u n\u1eb7ng trong nh\u00f3m hai l\u1ea7n m\u1ed7i ng\u00e0y (p = 0,46). Bi\u1ebfn c\u1ed1 ch\u1ea3y m\u00e1u nh\u1eb9 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng gi\u1eefa hai nh\u00f3m (2,4% \u1edf nh\u00f3m d\u00f9ng 1 l\u1ea7n\/ng\u00e0y v\u00e0 4,2%\u00a0 \u1edf nh\u00f3m hai l\u1ea7n m\u1ed7i ng\u00e0y (p = 0,69))<\/p>\n<p style=\"text-align: center;\"><strong><em>B\u1ea3ng 2. <\/em><\/strong><em>C\u00e1c ti\u00eau ch\u00ed ch\u00ednh<\/em><\/p>\n<p style=\"text-align: justify;\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-44202\" src=\"https:\/\/e1ship.com\/wp-content\/uploads\/2024\/08\/Danh-gia-tinh-an-toan-va-hieu-qua-cua-Enoxaparin_Bang-2.png\" alt=\"\" width=\"800\" height=\"379\" \/><\/p>\n<h2><strong>K\u1ebft lu\u1eadn<\/strong><\/h2>\n<p style=\"text-align: justify;\">D\u1ef1 ph\u00f2ng VTE b\u1eb1ng enoxaparin m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y c\u00f3 th\u1ec3 \u0111\u1ea3m b\u1ea3o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 tr\u00ean tr\u1ebb em. Kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ec9 l\u1ec7 bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i v\u00e0 xu\u1ea5t huy\u1ebft gi\u1eefa khi so vi\u1ec7c d\u00f9ng thu\u1ed1c hai l\u1ea7n m\u1ed7i ng\u00e0y. C\u00f3 th\u1ec3 c\u00e2n nh\u1eafc xem x\u00e9t vi\u1ec7c s\u1eed d\u1ee5ng enoxaparin m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y trong d\u1ef1 ph\u00f2ng. C\u1ea7n ti\u1ebfn h\u00e0nh th\u00eam c\u00e1c nghi\u00ean c\u1ee9u thu\u1ea7n t\u1eadp \u0111a trung t\u00e2m v\u1edbi c\u1ee1 m\u1eabu l\u1edbn h\u01a1n nh\u1eb1m x\u00e1c \u0111\u1ecbnh vai tr\u00f2 c\u1ee7a ch\u1ebf \u0111\u1ed9 li\u1ec1u enoxaparin m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y trong d\u1ef1 VTE cho tr\u1ebb em.<\/p>\n<p style=\"text-align: right;\"><strong>Bi\u00ean t\u1eadp: DS. Nguy\u1ec5n Th\u1ecb Ho\u00e0i Thu, DS. Nguy\u1ec5n Vi\u1ec7t Anh<\/strong><br \/>\n<strong>Khoa D\u01b0\u1ee3c &#8211; B\u1ec7nh vi\u1ec7n Nhi Trung \u01b0\u01a1ng<\/strong><br \/>\n<strong>Ngu\u1ed3n:<\/strong> The Journal of Pediatric Pharmacology and Therapeutics: 29(2):130-134.<br \/>\n<strong>DOI:<\/strong> 10.5863\/1551-6776-29.2.130<\/p>\n","protected":false},"excerpt":{"rendered":"<p>B\u1ed1i c\u1ea3nh v\u00e0 m\u1ee5c ti\u00eau nghi\u00ean c\u1ee9u Enoxaparin l\u00e0 m\u1ed9t heparin c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed th\u1ea5p v\u00e0 b\u1eb1ng kho\u1ea3ng 1\/3 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed c\u1ee7a heparin th\u00f4ng th\u01b0\u1eddng (kh\u00f4ng ph\u00e2n \u0111o\u1ea1n) (4.500\/12.000 daltons) v\u00e0 l\u00e0 m\u1ed9t thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng ti\u00eam ph\u1ed5 bi\u1ebfn hi\u1ec7n nay. M\u1ed9t trong c\u00e1c ch\u1ec9 \u0111\u1ecbnh quan tr\u1ecdng c\u1ee7a thu\u1ed1c [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":44203,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[666],"tags":[],"class_list":["post-44199","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ban-tin-thong-tin-thuoc"],"yoast_head":"\n<title>\u0110\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a Enoxaparin li\u1ec1u d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y so v\u1edbi hai l\u1ea7n m\u1ed7i ng\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng VTE \u1edf b\u1ec7nh nhi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/e1ship.com\/danh-gia-tinh-an-toan-va-hieu-qua-cua-enoxaparin-lieu-dung-mot-lan-moi-ngay.html\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0110\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a Enoxaparin li\u1ec1u d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y so v\u1edbi hai l\u1ea7n m\u1ed7i ng\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng VTE \u1edf b\u1ec7nh nhi\" \/>\n<meta property=\"og:description\" content=\"B\u1ed1i c\u1ea3nh v\u00e0 m\u1ee5c ti\u00eau nghi\u00ean c\u1ee9u Enoxaparin l\u00e0 m\u1ed9t heparin c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed th\u1ea5p v\u00e0 b\u1eb1ng kho\u1ea3ng 1\/3 kh\u1ed1i l\u01b0\u1ee3ng ph\u00e2n t\u1eed c\u1ee7a heparin th\u00f4ng th\u01b0\u1eddng (kh\u00f4ng ph\u00e2n \u0111o\u1ea1n) (4.500\/12.000 daltons) v\u00e0 l\u00e0 m\u1ed9t thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng ti\u00eam ph\u1ed5 bi\u1ebfn hi\u1ec7n nay. M\u1ed9t trong c\u00e1c ch\u1ec9 \u0111\u1ecbnh quan tr\u1ecdng c\u1ee7a thu\u1ed1c [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/e1ship.com\/danh-gia-tinh-an-toan-va-hieu-qua-cua-enoxaparin-lieu-dung-mot-lan-moi-ngay.html\" \/>\n<meta property=\"og:site_name\" content=\"B\u1ec7nh vi\u1ec7n Nhi Trung \u01b0\u01a1ng\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/bvnhitrunguong\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-20T03:30:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-21T03:49:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/e1ship.com\/wp-content\/uploads\/2024\/08\/Danh-gia-tinh-an-toan-va-hieu-qua-cua-Enoxaparin_Avatar.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"366\" \/>\n\t<meta property=\"og:image:height\" content=\"236\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"quantriad2\" \/>\n<meta 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